Trichloroacetic acid (TCA) is widely used in analytical chemistry as a standard sample for calibration and quality control in various testing procedures. It serves as a reference material in environmental analysis to detect chlorinated compounds in water, soil, and biological samples. TCA is also employed in protein precipitation during biochemical sample preparation, enabling the isolation of nucleic acids and other macromolecules. In clinical laboratories, it aids in the determination of serum proteins and metabolic byproducts. Its high purity as a standard ensures accurate quantification and reliable results in chromatographic and spectrophotometric methods. Additionally, TCA is utilized in stability studies and method validation to assess the performance of analytical systems.