Used primarily in veterinary medicine to treat bacterial infections in livestock and poultry, especially respiratory, gastrointestinal, and urinary tract infections caused by susceptible organisms. It acts by inhibiting bacterial growth through competitive inhibition of dihydropteroate synthase, disrupting folic acid synthesis essential for DNA and bacterial cell replication. Commonly administered in feed or drinking water for the prevention and treatment of coccidiosis in combination with other agents such as trimethoprim. Also applied in aquaculture to control bacterial diseases. Its long-acting sulfonamide properties make it effective for sustained antimicrobial activity. Popular in farms for cattle, buffalo, pigs, and poultry. Due to concerns over residues and antimicrobial resistance, its use is regulated in many countries, with established withdrawal periods before animal products can be safely consumed.