Salicylic acid (≥99% purity) is commonly used in plant cell culture as a signaling molecule to induce systemic acquired resistance and study plant defense responses.

Additionally, it is widely used in skincare products for its keratolytic and comedolytic properties, helping to exfoliate the skin, unclog pores, and treat acne by reducing inflammation, swelling, and redness while promoting the shedding of dead skin cells. It is found in cleansers, toners, and spot treatments. It also aids in managing skin conditions such as psoriasis and seborrheic dermatitis by reducing scaling. In higher concentrations, it effectively removes warts and calluses. In hair care, it combats dandruff and scalp buildup. Its anti-inflammatory effects make it valuable in over-the-counter and prescription topical formulations.

In pharmaceuticals, salicylic acid serves as a key intermediate in the synthesis of aspirin (acetylsalicylic acid), a common analgesic, antipyretic, and anti-inflammatory drug. It is also used in topical treatments for fungal skin infections, such as warts and onychomycosis (nail fungus).

Minor applications include use as a preservative or fragrance component in food and perfumery, though in limited quantities.