Sulfacetamide is widely used in topical antimicrobial formulations, particularly in ophthalmic and dermatological preparations. It is effective in treating bacterial infections of the eye, such as conjunctivitis and blepharitis, due to its ability to inhibit the growth of susceptible strains of bacteria by interfering with folic acid synthesis. In dermatology, it is commonly found in acne and seborrheic dermatitis treatments, often combined with sulfur or other agents to reduce inflammation and control bacterial overgrowth on the skin. Its topical application provides localized action with minimal systemic absorption, making it a safe option for long-term management of chronic skin conditions.