Sulfolane is widely used as a solvent in the petrochemical industry, especially in aromatic extraction processes. It effectively separates aromatic hydrocarbons like benzene, toluene, and xylene from hydrocarbon mixtures due to its high selectivity and thermal stability. This makes it essential in refining operations where high-purity aromatics are required for producing plastics, synthetic fibers, and other chemical intermediates.

It is also employed in natural gas processing to remove impurities such as hydrogen sulfide and carbon dioxide from sour gas streams. Its ability to perform under high temperatures and pressures without significant degradation enhances its suitability in gas sweetening units.

Additionally, sulfolane finds use in some electrochemical applications and as a reaction medium in organic synthesis where a polar, aprotic solvent is needed. Its stability and solvating power support efficient chemical transformations in industrial processes.