Sulfacetamide is widely used in topical antimicrobial treatments, particularly in ophthalmic and dermatological preparations. It is effective against a range of bacterial infections due to its ability to inhibit bacterial synthesis of folic acid, which is essential for growth. In eye care, it is commonly formulated in eye drops or ointments to treat bacterial conjunctivitis and other external eye infections. Its low irritation potential and good solubility make it suitable for use in sensitive areas like the eyes. In dermatology, sulfacetamide is used to manage acne vulgaris and seborrheic dermatitis, especially when associated with bacterial overgrowth. It is often combined with other agents like sulfur to enhance its anti-inflammatory and antibacterial effects. The formulation helps reduce inflammatory lesions and control excess oil and bacteria on the skin. Due to its topical application and limited systemic absorption, it offers a favorable safety profile with minimal risk of widespread side effects.