Widely used as a strong non-nucleophilic base in organic synthesis, it facilitates deprotonation of weakly acidic protons in sensitive compounds. Commonly employed in the preparation of enolates, organometallic reagents, and in lithiation reactions when combined with lithium salts. It is especially useful in the synthesis of pharmaceuticals and fine chemicals where high reactivity and selectivity are required. Its solubility in nonpolar solvents makes it ideal for use in aprotic environments. Also applied in the generation of anions in polymerization initiators and in the modification of silicon surfaces in semiconductor processing.