Piroxicam is widely used as a nonsteroidal anti-inflammatory drug (NSAID) for the management of inflammatory and degenerative joint diseases such as rheumatoid arthritis and osteoarthritis. It helps reduce pain, swelling, stiffness, and joint discomfort associated with these conditions. Due to its long half-life, it allows for once-daily dosing, improving patient compliance. It is also used in the treatment of ankylosing spondylitis and other musculoskeletal disorders involving inflammation. Piroxicam works by inhibiting cyclooxygenase (COX) enzymes, thereby reducing the production of prostaglandins that mediate pain and inflammation. It is available in oral, tablet, capsule, and topical formulations, with topical use beneficial for localized pain and inflammation with potentially fewer systemic side effects.