Used as a green solvent in organic synthesis, particularly in pharmaceutical and fine chemical manufacturing due to its low toxicity and biodegradability. It serves as an alternative to traditional volatile organic solvents like tetrahydrofuran (THF) and dichloromethane. MeTHF is effective in Grignard reactions, metal-catalyzed couplings, and hydrogenation processes because of its ability to stabilize reactive intermediates and compatibility with various reagents. Its higher boiling point and lower water solubility facilitate easier product isolation and phase separation in aqueous workups. Also explored in extraction processes and as a reaction medium in renewable feedstock-based chemistry.