Used extensively in gel filtration chromatography for desalting and buffer exchange of biomolecules such as proteins, peptides, and nucleic acids. It effectively separates small molecules like salts from larger macromolecules based on size exclusion, making it ideal for purification and cleanup steps in protein chemistry and molecular biology workflows. Commonly used after precipitation or labeling reactions to remove unincorporated dyes, reagents, or salts. Available in different forms (e.g., fine, medium, coarse, superfine) to suit various column and filtration setups, including spin columns for rapid processing.