Florisil is widely used as an adsorbent in solid-phase extraction (SPE) and column chromatography for the separation and purification of various organic compounds. It is particularly effective in the cleanup of environmental and food samples prior to analysis for pesticides, herbicides, and other contaminants. Due to its strong polar retention properties, Florisil efficiently removes interfering matrix components such as pigments, fats, and sterols from complex mixtures. It is commonly applied in the analysis of fat-soluble vitamins, hormones, and persistent organic pollutants (POPs) like PCBs and dioxins. Florisil is also used in the petrochemical industry for hydrocarbon group-type separations. Its high thermal stability allows it to be activated and reused after conditioning, making it a cost-effective choice in both analytical and preparative-scale applications.