Florisil is widely used as an adsorbent in solid-phase extraction (SPE) for the cleanup and separation of complex mixtures, especially in environmental and food testing. It is effective in removing interfering compounds such as pigments, fats, and sulfur-containing substances from sample extracts. Commonly applied in pesticide residue analysis, Florisil helps isolate target analytes from plant and animal tissues, ensuring cleaner samples for gas chromatography or mass spectrometry. It is also used in the purification of pharmaceuticals and natural products due to its ability to separate polar and nonpolar compounds. Its magnesium silicate base provides strong polar interaction, making it ideal for normal-phase chromatography applications.