Cloperastine hydrochloride is primarily used as an antitussive agent in the treatment of cough. It works by suppressing the cough reflex through central action on the cough center in the medulla oblongata. This makes it effective in managing dry, non-productive coughs associated with conditions like bronchitis, pharyngitis, and upper respiratory tract infections. Due to its dual action—both antitussive and mild antihistaminic properties—it helps reduce cough frequency and soothe throat irritation. It is commonly formulated in syrup, tablets, or drops and is often included in combination with other respiratory medications for enhanced symptomatic relief.