Clofibrate is primarily used to lower high levels of lipids, particularly triglycerides and cholesterol, in the blood. It helps reduce the risk of pancreatitis in patients with very high triglyceride levels. As a lipid-lowering agent, it is prescribed when dietary changes and lifestyle modifications are not sufficient. Clofibrate belongs to the class of fibrates, which work by increasing the breakdown of lipids in the liver and reducing their production. It may also improve the profile of lipoproteins, helping to manage certain types of hyperlipidemia. Though less commonly used today due to newer alternatives, it has been historically significant in cardiovascular risk management.