Gamma-aluminum oxide (γ-Al₂O₃) nanoparticles are primarily used as a high-surface-area catalyst support in chemical reactions, including petroleum refining and hydrogenation processes. They serve as effective adsorbents for water purification, removing contaminants like fluoride and arsenic. In advanced ceramics, they enhance mechanical properties and thermal stability. Employed as fillers in composites and coatings for improved durability. Due to biocompatibility, used in biomedical applications such as drug delivery systems and tissue engineering scaffolds. Also applied in electronics for dielectric materials and in energy storage devices like lithium-ion batteries.