Used as a titrant in non-aqueous acid-base titrations to determine the concentration of weak acids, especially in pharmaceutical analysis. It is commonly employed in the assay of organic acids that are poorly soluble or do not dissociate well in water. Its role as a base in non-aqueous solvents like glacial acetic acid allows for sharp, clear endpoints when using indicators such as crystal violet or potentiometric detection. Frequently applied in quality control for raw materials and active pharmaceutical ingredients where precise neutralization is required.