Tripelennamine hydrochloride is primarily used as an antihistamine to alleviate symptoms associated with allergic reactions, such as itching, sneezing, and runny nose. It works by blocking histamine receptors, reducing the body's response to allergens. This compound is often found in medications for treating hay fever, hives, and other allergic skin conditions. Additionally, it may be used in veterinary medicine to manage allergic reactions in animals. Its sedative properties also make it useful in formulations aimed at providing relief from mild anxiety or insomnia in some cases.