Clofibrate is primarily used in the treatment of high cholesterol and triglyceride levels in the blood. It works by lowering the production of triglycerides in the liver and increasing the removal of cholesterol from the bloodstream. This helps reduce the risk of cardiovascular diseases such as heart attacks and strokes. It is often prescribed when diet and lifestyle changes alone are not sufficient to manage lipid levels. Additionally, clofibrate may be used in certain cases to treat conditions like hyperlipidemia and xanthomatosis, where abnormal lipid deposits occur in the skin. It is typically administered orally and is most effective when combined with a healthy diet and regular exercise. However, its use has declined in recent years due to the availability of newer, more effective lipid-lowering medications with fewer side effects.