Widely used in organic synthesis as a sulfonylating agent, particularly in the preparation of sulfonamides, which are key motifs in pharmaceuticals and agrochemicals. It reacts readily with amines to form sulfonamide derivatives, enabling the development of bioactive molecules. Its electron-withdrawing trifluoromethyl group enhances reactivity and stability of the resulting products. Commonly employed in medicinal chemistry for structure–activity relationship studies and in the synthesis of functional materials. Also utilized as an intermediate in the production of dyes, polymers, and specialty chemicals where enhanced lipophilicity and metabolic stability are desired.