Tetraphenylethylene is widely used in the development of organic luminescent materials due to its strong fluorescence and aggregation-induced emission (AIE) properties. It serves as a key building block in the design of sensors for detecting explosives, pollutants, and biomolecules, as its emission intensifies in aggregated states, making it highly sensitive in solid or restricted environments.

It is also employed in optoelectronic devices such as organic light-emitting diodes (OLEDs), where it contributes to efficient light emission with low background noise. Its rigid structure and ability to resist self-quenching support enhanced device stability and performance.

In addition, tetraphenylethylene derivatives are explored in bioimaging applications because of their low toxicity and high emission in cellular environments. These compounds can penetrate cell membranes and provide clear fluorescent signals for tracking biological processes.

Its unique AIE behavior also makes it suitable for use in smart materials, including stimuli-responsive systems that change fluorescence in response to mechanical stress, temperature, or chemical exposure.