Tris(pentafluorophenyl)phosphine is widely used as a ligand in organometallic chemistry and catalysis. Its strong electron-withdrawing properties make it especially effective in stabilizing highly reactive metal centers in catalytic systems. It is commonly employed in olefin polymerization and hydrogenation reactions, particularly with early transition metals and f-block elements. The compound plays a key role in frustrated Lewis pair (FLP) chemistry, where it participates in the activation of small molecules such as hydrogen and carbon dioxide. Due to its steric bulk and electron-deficient nature, it enables metal-free catalysis, offering a valuable alternative to traditional transition metal catalysts in certain transformations. It is also used in the development of new catalysts for hydrofunctionalization and carbon-carbon bond formation reactions.