1-(Trimethylsilyl)propyne is the trimethylsilyl-protected form of propyne (CH₃C≡CH), serving as a key intermediate in organic synthesis. The silyl group masks the terminal alkyne, preventing unwanted reactivity during multistep sequences and allowing selective modifications elsewhere in the molecule. Deprotection is straightforward under mild conditions, such as treatment with fluoride ions (e.g., TBAF) or weak acids, to regenerate the free terminal alkyne. This compound is widely used in the preparation of natural products, pharmaceuticals, and conjugated systems where alkyne functionality is required later in the synthesis. It also functions as a protected alkyne precursor in cross-coupling reactions, including Sonogashira couplings, facilitating the introduction of the propyne unit.