Trimesic acid is widely used in the synthesis of metal-organic frameworks (MOFs) due to its ability to form stable, rigid three-dimensional structures with metal ions. These MOFs have applications in gas storage, separation, and catalysis. Its symmetrical structure with three carboxylic acid groups makes it ideal for constructing porous materials with high surface areas.

It is also employed in the production of covalent organic frameworks (COFs), where it contributes to the formation of robust, ordered networks used in sensing, drug delivery, and environmental remediation.

In polymer chemistry, trimesic acid acts as a cross-linking agent, enhancing thermal and mechanical stability of resins and coatings. It is used in the formulation of high-performance polymers and thermosetting materials.

Additionally, it finds use in analytical chemistry as a complexing agent for metal ion detection and separation. Its derivatization is applied in the development of sensors and selective absorbents for environmental monitoring.