Used as a key reagent in organic synthesis, particularly in Sonogashira coupling reactions, where it introduces a trimethylsilyl-protected alkyne group. This allows for the controlled formation of carbon–carbon bonds in the construction of complex molecules, including pharmaceuticals and advanced materials. The trimethylsilyl (TMS) group acts as a protecting group that can be easily removed under mild conditions, enabling further functionalization downstream. It is especially valuable in the synthesis of conjugated enynes and alkynoic derivatives used in medicinal chemistry and materials science. Its stability and reactivity profile make it suitable for multi-step synthetic sequences.