Naspm is primarily utilized in neuroscience research as a selective antagonist for calcium-permeable AMPA receptors. These receptors play a critical role in synaptic plasticity and neuronal communication. By blocking these receptors, Naspm helps scientists study the mechanisms underlying various neurological conditions, such as epilepsy, stroke, and neurodegenerative diseases. Its application is particularly valuable in understanding the role of calcium influx in excitotoxicity, a process linked to cell damage and death in the brain. Additionally, Naspm is used in electrophysiological studies to dissect the contributions of specific receptor subtypes to neuronal signaling pathways. This makes it a crucial tool for advancing knowledge in brain function and developing potential therapeutic strategies for neurological disorders.