D-Serine plays a crucial role in the central nervous system as a co-agonist at the NMDA (N-methyl-D-aspartate) receptor, which is essential for synaptic plasticity, learning, and memory. It is used in neuroscience research to study the mechanisms of neurotransmission and to explore its potential in treating neurological disorders such as schizophrenia, where NMDA receptor dysfunction is implicated. Additionally, D-Serine is investigated for its therapeutic potential in conditions like stroke, Alzheimer's disease, and depression, as modulating NMDA receptor activity can influence neuronal health and cognitive functions. Its application in clinical trials aims to develop treatments that can enhance or restore normal NMDA receptor function, offering hope for improved outcomes in various brain-related diseases.