Z-Homophe-OH is primarily utilized in peptide synthesis and biochemical research. It serves as a building block for constructing peptide chains, particularly in studies involving enzyme-substrate interactions and receptor binding. Its unique structure allows it to mimic natural amino acids, making it valuable in designing peptide-based drugs and studying protein folding. Additionally, it is employed in the development of bioactive peptides for therapeutic applications, such as antimicrobial or anticancer agents. Researchers also use it to explore the structure-activity relationships of peptides, aiding in the optimization of peptide-based therapeutics.