L-Ornithine monohydrochloride is widely used in the pharmaceutical and nutraceutical industries. It is commonly incorporated into dietary supplements aimed at supporting liver health, as it plays a role in the urea cycle, helping to detoxify ammonia in the body. This makes it beneficial for individuals with liver conditions or those recovering from alcohol-related liver damage. Additionally, it is utilized in sports nutrition products to enhance athletic performance and reduce fatigue by aiding in the removal of metabolic waste products like lactic acid. In medical formulations, it is sometimes included in solutions for parenteral nutrition to support patients with metabolic disorders or those requiring amino acid supplementation. Its role in promoting muscle recovery and overall metabolic health further extends its application in health and wellness products.

Furthermore, L-Ornithine monohydrochloride is included in some supplements to improve sleep quality, potentially through stimulation of growth hormone release. It is also used in cosmetic products to stimulate collagen production and aid in skin rejuvenation.