L-Histidine is widely used in the medical field as a dietary supplement to support overall health, particularly in individuals with histidine deficiency or certain metabolic disorders. It plays a crucial role in the synthesis of proteins and is a precursor to histamine, which is essential for immune response, digestion, and sleep-wake cycles. In clinical settings, it is administered to manage conditions like rheumatoid arthritis due to its anti-inflammatory properties. Additionally, L-Histidine is utilized in the production of pharmaceuticals and infusion solutions for patients requiring nutritional support. It is also incorporated into skincare products for its antioxidant properties, helping to protect the skin from oxidative stress and improve its barrier function.