Widely used in peptide synthesis, this compound serves as a protected amino acid derivative, specifically for histidine residues with defined stereochemistry. Its Fmoc group allows for mild base-labile protection, enabling stepwise assembly of peptides in solid-phase synthesis. The imidazole side chain remains stable during coupling and deprotection steps, making it ideal for preparing biologically active peptides that require histidine for function or structure. It is especially valuable in pharmaceutical research, including the development of peptide-based drugs and diagnostic agents.