Used in peptide synthesis as a protected histidine derivative, enabling selective coupling and solid-phase synthesis. The Fmoc group allows for mild deprotection under basic conditions, making it compatible with standard Fmoc-strategy protocols. The 1-methyl substitution prevents unwanted side reactions at the imidazole ring during elongation, improving yield and purity in the preparation of complex peptides. Commonly employed in the synthesis of bioactive peptides and pharmaceutical intermediates where histidine residues are present.