Used in peptide synthesis, particularly in the development of bioactive peptides and pharmaceutical research. The difluoromethyl (CF2H) group on the tyrosine residue enhances metabolic stability and modulates lipophilicity, making it valuable in optimizing peptide drug candidates. The Fmoc protection allows for solid-phase peptide synthesis using standard Fmoc/tBu strategies, enabling efficient incorporation into complex peptide sequences. Commonly applied in medicinal chemistry for creating enzyme inhibitors, receptor ligands, and probes for biological studies where improved pharmacokinetic properties are required.