Fmoc-D-Threoninol is widely used in peptide synthesis and organic chemistry as a chiral building block. Its primary application lies in the construction of complex peptides and peptidomimetics, where the D-threoninol backbone provides stereochemical control and metabolic stability. The Fmoc (fluorenylmethyloxycarbonyl) group allows for mild, base-labile protection of the amino function, making it fully compatible with standard Fmoc solid-phase peptide synthesis (SPPS) protocols. It is especially valuable in the development of bioactive peptides with enhanced resistance to enzymatic degradation, due to the presence of the D-configured amino alcohol structure. This compound also serves as a scaffold in combinatorial chemistry and drug discovery, enabling the introduction of functionalized side chains or labels at specific positions in a peptide sequence. Additionally, Fmoc-D-Threoninol is employed in the synthesis of glycopeptides and other modified peptides where precise stereochemistry and orthogonal protection are critical. Its hydroxyl group can be selectively modified, allowing for conjugation with sugars, lipids, or fluorescent tags. This versatility makes it a key reagent in the design of therapeutic candidates, biochemical probes, and synthetic vaccines.