(4S)-3-(9H-fluoren-9-ylmethoxycarbonyl)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
98%
Reagent
Code: #186733
CAS Number
141636-66-0
blur_circular Chemical Specifications
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Molecular Information
Weight
383.46 g/mol
Formula
C₂₁H₂₁NO₄S
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Registry Numbers
MDL Number
MFCD02682321
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Physical Properties
Melting Point
65-73 °C
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Storage & Handling
Storage
2-8°C, sealed, dry
description Product Description
Widely used in peptide synthesis as a chiral auxiliary and protecting group carrier, this compound enables stereoselective construction of complex peptides. The thiazolidine ring acts as a scaffold for amino acid assembly, while the fluorenylmethoxycarbonyl (Fmoc) group provides orthogonal protection for the amine functionality, allowing stepwise chain elongation in solid-phase peptide synthesis. Its rigid structure helps control stereochemistry during coupling reactions, improving yield and purity. Commonly employed in the preparation of biologically active peptides and peptidomimetics, it supports the synthesis of pharmaceuticals and biochemical probes. The compound’s stability under various reaction conditions and clean deprotection profile make it valuable in automated and high-throughput peptide manufacturing.
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