N-(tert-Butyl)-3-nitrobenzenesulfonamide is an organic compound utilized as an intermediate in organic synthesis. It features the 3-nitrobenzenesulfonyl (Nosyl) group, which is widely used as a protecting group for amines, with the tert-butyl substituent providing steric hindrance, enhanced solubility in organic solvents, and stability under synthetic conditions. This compound serves in the preparation of complex sulfonamides and related derivatives, finding applications in the development of pharmaceuticals, agrochemicals, and fine chemicals. The electron-withdrawing nitro group activates the sulfonyl functionality for selective reactions.