Used as a protecting group for amines in organic synthesis, particularly in peptide and heterocyclic chemistry. The N-benzyl-4-nitrobenzenesulfonamide moiety can be selectively introduced to mask amine functionality, preventing unwanted side reactions during multistep syntheses. It is stable under various reaction conditions but can be removed selectively using nucleophiles like thiols or amines, especially under mild basic or neutral conditions. Its electron-withdrawing nitro group enhances the lability of the sulfonamide bond, facilitating deprotection when needed. This makes it valuable in the synthesis of complex molecules where precise control over functional group reactivity is required.