Used as a reagent in organic synthesis, particularly in the preparation of sulfonamides and carbamates. It acts as a protecting group for amines due to the stability of the tert-butyl moiety under various reaction conditions. The methylsulfonyl group enhances electrophilicity, facilitating nucleophilic attack during coupling reactions. Commonly employed in medicinal chemistry for the development of pharmaceutical intermediates where selective amine functionalization is required. Its application extends to peptide synthesis and the construction of nitrogen-containing heterocycles.