Used as a key reagent in organic synthesis, particularly in the preparation of sulfonamide derivatives and heterocyclic compounds. It serves as a mesitylsulfonyl (MesSO₂) protecting or activating group in peptide synthesis and medicinal chemistry. Its stability and reactivity make it suitable for facilitating nucleophilic substitution reactions, especially in the development of pharmaceutical intermediates. Commonly employed in research settings for modifying amine functionalities and enhancing reaction selectivity under mild conditions.