N,N'-Diisopropylethylenediamine is widely used as a ligand in coordination chemistry, particularly in the synthesis of metal complexes. Its ability to form stable complexes with various metals makes it valuable in catalysis, especially in asymmetric synthesis where it helps in achieving high enantioselectivity.

In organic synthesis, it serves as a base or a nucleophile in various reactions, including the formation of amides, esters, and other nitrogen-containing compounds. Its steric bulk and basicity are advantageous in deprotonation reactions and in facilitating the formation of specific intermediates.

Additionally, it finds application in the pharmaceutical industry, where it is used in the preparation of active pharmaceutical ingredients (APIs) and in the development of drug candidates. Its role in modifying the pharmacokinetic properties of drugs is also noteworthy.

In polymer chemistry, N,N'-Diisopropylethylenediamine is utilized in the synthesis of polyamides and polyurethanes, contributing to the material's stability and performance. Its incorporation into polymers can enhance properties such as thermal stability and mechanical strength.