Acetamidine Hydroiodide is primarily utilized in organic synthesis as a reagent for the preparation of amidines, which are valuable intermediates in the production of various pharmaceuticals and agrochemicals. It is particularly effective in the synthesis of heterocyclic compounds, which are crucial in the development of drugs targeting a range of diseases. Additionally, this compound is employed in the modification of peptides and proteins, aiding in the study of their structure and function. Its role in facilitating specific chemical reactions makes it a significant tool in medicinal chemistry and biochemical research.