Tribromoacetamide is primarily used as an intermediate in organic synthesis, especially in the preparation of other brominated compounds. It serves as a brominating agent in certain chemical transformations where controlled introduction of bromine is required. Due to its reactivity, it finds use in pharmaceutical research for modifying molecular structures, particularly in the development of bioactive molecules and antimicrobial agents. It is also employed in some polymer chemistry applications as a modifying agent to introduce flame-retardant properties. Its utility in research laboratories includes use in the study of reaction mechanisms involving halogen transfer. Handling requires caution due to its potential instability and irritant properties.