Trimethyl(p-tolylethynyl)silane
98%
Reagent
Code: #132281
CAS Number
4186-14-5
blur_circular Chemical Specifications
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Molecular Information
Weight
188.34 g/mol
Formula
C₁₂H₁₆Si
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Registry Numbers
MDL Number
MFCD22687753
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Storage & Handling
Storage
2-8°C
description Product Description
Used as a reagent in organic synthesis, particularly in Sonogashira coupling reactions, where it serves as a silyl-protected alkyne equivalent. The trimethylsilyl group stabilizes the ethynyl functionality and enhances reactivity and selectivity during cross-coupling. After coupling, the silyl group can be removed under mild conditions to reveal the terminal alkyne, making it valuable in the construction of conjugated enynes and arylalkyne systems found in pharmaceuticals, agrochemicals, and advanced materials. Its stability and ease of handling make it suitable for multi-step syntheses.
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