tert-Butyl 3-phenylpropiolate
98%
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Used as a key intermediate in organic synthesis, particularly in the preparation of complex natural products and pharmaceuticals. Its alkyne functionality allows participation in click chemistry reactions, such as copper-catalyzed azide-alkyne cycloaddition (CuAAC), enabling efficient construction of triazole rings. Frequently employed in palladium-catalyzed coupling reactions, including Sonogashira and Heck reactions, to form carbon-carbon bonds in conjugated systems. Also serves as a building block in the synthesis of flavonoids, stilbenes, and other biologically active molecules. Its tert-butyl ester group offers stability and ease of deprotection under mild acidic conditions, making it valuable in multi-step synthetic sequences.
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