Thalidomide-propargyl is primarily used in medicinal chemistry and drug development due to its potential therapeutic properties. It is often employed as a building block in the synthesis of more complex molecules, particularly in the creation of targeted cancer therapies. Its propargyl group allows for efficient conjugation with other compounds through click chemistry, enabling the development of novel drug candidates. Additionally, it is studied for its anti-inflammatory and immunomodulatory effects, making it a candidate for treating conditions like multiple myeloma and other inflammatory diseases. Researchers also explore its potential in inhibiting angiogenesis, which is crucial in controlling tumor growth.