Used primarily in the treatment of colorectal cancer, this compound is a key component in chemotherapy regimens, often combined with 5-fluorouracil and leucovorin (FOLFOX). It functions by binding to DNA and forming crosslinks, which disrupt DNA replication and transcription, ultimately leading to cancer cell death. Its effectiveness extends to both early-stage and metastatic colorectal cancers. Due to its mechanism, it is also explored in the treatment of other gastrointestinal malignancies. The stereochemistry enhances its cytotoxic activity and influences its pharmacokinetics, contributing to its clinical efficacy.