1-((Trimethylsilyl)ethynyl)cyclopropane-1-carboxylic acid
98%
Reagent
Code: #243248
CAS Number
1268810-07-6
blur_circular Chemical Specifications
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Molecular Information
Weight
182.29 g/mol
Formula
C₉H₁₄O₂Si
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Registry Numbers
MDL Number
MFCD20660917
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Storage & Handling
Storage
Room temperature, inert gas
description Product Description
Used as a key intermediate in organic synthesis, particularly in the preparation of pharmaceuticals and agrochemicals. Its alkyne functionality, protected by a trimethylsilyl group, allows for selective deprotection and coupling reactions, such as Sonogashira cross-coupling, enabling the construction of complex molecular architectures. The cyclopropane ring adds strain and rigidity, which can enhance binding selectivity in bioactive molecules. Commonly employed in medicinal chemistry for modifying lead compounds to improve metabolic stability and pharmacokinetic properties.
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