Used as a key building block in medicinal chemistry, particularly in the synthesis of bioisosteres for phenyl and other aromatic rings. Its rigid, three-dimensional structure helps improve metabolic stability, solubility, and binding selectivity in drug candidates. Commonly employed in the development of CNS drugs, agrochemicals, and PET tracers due to its ability to modulate physicochemical properties and enhance pharmacokinetic profiles. The carboxylic acid group allows for easy derivatization into amides, esters, and other functional groups, facilitating rapid exploration of structure-activity relationships.