Widely used in medicinal chemistry as a bioisostere for phenyl or tert-butyl groups, enhancing metabolic stability and solubility in drug candidates. Its rigid three-dimensional structure improves target selectivity and reduces off-target effects. Commonly incorporated into small molecule therapeutics to modulate pharmacokinetic properties, especially in CNS and oncology drugs. Also used in agrochemicals to improve environmental stability and efficacy. Serves as a building block in fragment-based drug design due to favorable ligand efficiency and low molecular weight.