1-Iodo-1-propyne is primarily used in organic synthesis as a versatile building block for creating more complex molecules. It is particularly valuable in the formation of carbon-carbon bonds through coupling reactions, such as Sonogashira coupling, which is widely employed in the synthesis of alkynes. This compound is also utilized in the preparation of pharmaceuticals, agrochemicals, and advanced materials due to its reactive iodine and alkyne functional groups. Additionally, it serves as a precursor in the development of organic electronic materials and polymers, where its properties contribute to the desired conductivity or structural characteristics. Its applications extend to research and development in medicinal chemistry, where it aids in the exploration of new drug candidates.