1-Pentynyl iodide is primarily used in organic synthesis as a building block for more complex molecules. Its terminal alkyne group makes it a valuable reagent in coupling reactions, such as Sonogashira coupling, which is widely employed in the synthesis of pharmaceuticals, agrochemicals, and advanced materials. The compound is also utilized in the preparation of heterocyclic compounds and functionalized alkynes, which are essential in drug discovery and material science. Additionally, it serves as a precursor in the synthesis of natural products and bioactive molecules, contributing to the development of new therapeutic agents. Its reactivity with various nucleophiles and electrophiles further expands its applications in creating diverse chemical structures.